Human CellExp™ MSR1/CD204, human recombinant

Catalog number
7390-10
Name
Human CellExp™ MSR1/CD204, human recombinant
Size
10 μg
Price
246.00 EUR
Supplier

Details

Target
MSR1/CD204
Background
Macrophage scavenger receptor 1 (MSR1) also known as CD204, SCARA1, SR-A, and is class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. Defects in MSR1 may be a cause of prostate cancer (PC) or Barrett esophagus (BE).
Concentration
N/A
Molecular weight
This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 42.1 kDa. The predicted N-terminus is Lys 77. DTT-reduced Protein migrates as 65-72 kDa due to glycosylation.
Synonym
MSR1, CD204, SCARA1, SR-A, phSR1, phSR2
Other name
MSR1, CD204, SCARA1, SR-A, phSR1, phSR2
NCBI gene number
4481
NCBI gene
MSR1
Gene source
Human
NCBI number
P21757
Recombinant
Yes
Source
HEK293 cells
Purification
≥95%
Tested applications
SDS-PAGE, N/A
Tested activity
N/A
Biological activity
Measured by its binding ability in a functional ELISA. Immobilized rhMSR1 at 5 µg/ml (100 µl/well) can bind biotinylated advanced glycation end products of bovine serum albumin (AGE-BSA, Cat # 2221-10) with a linear range of 1 - 150 ng/ml.
Reesults
Measured by its binding ability in a functional ELISA. Immobilized rhMSR1 at 5 µg/ml (100 µl/well) can bind biotinylated advanced glycation end products of bovine serum albumin (AGE-BSA, Cat # 2221-10) with a linear range of 1 - 150 ng/ml.
Binding ability
N/A
Unit
N/A
Storage condition
-20°C
Shipping under
Gel Pack
Physical appearance
Lyophilized
Physical properties
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
How to reconstitute
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants