Quizartinib for cell activation

Catalog number
2008-5
Name
Quizartinib for cell activation
Size
5 mg
Price
420.00 EUR
Supplier

Details

Description
Cell-permeable. A second generation FLT3 receptor tyrosine kinase inhibitor. Quizartinib displays high affinity for FLT3 in a binding assay (Kd = 1.6 nM) and is a potent inhibitor in cellular autophosphorylation assays (IC₅₀ = 1.1 nM for FLT3-ITD and 4.2 nM for wt FLT3). It inhibits the growth of human leukemia cell line MV4-11 (IC₅₀0 = 0.56 nM) which is FLT3 dependent and contains a homozygous FLT3-ITD mutation, and A375 cells (IC50> 10,000 nM) which are not FLT3 dependent and contain an activating mutation in BRAF.
Peptide sequence
N/A
CAS number
950769-58-1
Molecular weight
560.67
Category
Biochemicals
Other name
AC220; AC010220
Molecular formula
C₂₉H₃₂N₆O₄S
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥99% by HPLC
Reconstitute instructions
DMSO (~200 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.