Neratinib for cell activation

Catalog number
2023-5
Name
Neratinib for cell activation
Size
5 mg
Price
251.00 EUR
Supplier

Details

Description
Cell-permeable. A second-generation inhibitor of the ErbB family of receptor kinases. Neratinib acts as an irreversible inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) tyrosine kinases by targeting a cysteine residue in the ATP-binding site of the receptor. It inhibits the proliferation of HER-2 overexpressing human breast cancer cell lines and EGFR-dependent cells in vitro.
Peptide sequence
N/A
CAS number
698387-09-6
Molecular weight
557.04
Category
Biochemicals
Other name
HKI-272
Molecular formula
C₃₀H₂₉ClN₆O₃
Physical appearance
Off-white to pale yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~ 2 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.