Vatalanib, Free Base for cell activation

Catalog number
2026-5
Name
Vatalanib, Free Base for cell activation
Size
5 mg
Price
126.00 EUR
Supplier

Details

Description
Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀> 10 µM).
Peptide sequence
N/A
CAS number
212141-54-3
Molecular weight
346.81
Category
Biochemicals
Other name
CGP-79787; PTK 787; ZK222584
Molecular formula
C₂₀H₁₅ClN₄
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (25 mg/ml) or EtOH (~ 6 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.