Human CellExp™ IL13RA1/CD213A1, human recombinant

Catalog number
7433-50
Name
Human CellExp™ IL13RA1/CD213A1, human recombinant
Size
50 μg
Price
719.00 EUR
Supplier

Details

Target
IL13RA1/CD213A1
Background
Interleukin 13 receptor, alpha 1, also known as IL13RA1, NR4 and CD213A1 (cluster of differentiation 213A1), The IL13 Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. Human and mouseIL13Rα1 share 76% aa sequence identity. IL13RA1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
Concentration
N/A
Molecular weight
This protein is fused with a 6×his tag at the C-terminus and the protein has a calculated MW of 38 kDa. DTT-reduced protein migrates as 55-65 kDa in SDS-PAGE due to glycosylation.
Synonym
IL13RA1, CD213A1, IL-13Ra, NR4, RP13-128O4.2, IL13Rα1
Other name
IL13RA1, CD213A1, IL-13Ra, NR4, RP13-128O4.2, IL13Rα1
NCBI gene number
3597
NCBI gene
IL13RA1
Gene source
Human
NCBI number
P78552
Recombinant
Yes
Source
HEK293 cells
Purification
≥98%
Tested applications
SDS-PAGE, N/A
Tested activity
N/A
Biological activity
Measured by its binding ability in a functional ELISA. Immobilized rhIL13Ra1 at 2 μg/mL (100 μL/well) can bind rhIL13 with a linear range of 0.1-10 ng/mL.
Reesults
Measured by its binding ability in a functional ELISA. Immobilized rhIL13Ra1 at 2 μg/mL (100 μL/well) can bind rhIL13 with a linear range of 0.1-10 ng/mL.
Binding ability
N/A
Unit
N/A
Storage condition
-20°C
Shipping under
Gel Pack
Physical appearance
Lyophilized
Physical properties
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
How to reconstitute
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants