Sphingosine Kinase Inhibitor, SKI-II for cell activation

Catalog number
2047-25
Name
Sphingosine Kinase Inhibitor, SKI-II for cell activation
Size
25 mg
Price
675.00 EUR
Supplier

Details

Description
Cell-permeable. SKI-II is selective a non-lipid sphingosine kinase (SK) inhibitor. It displays non-ATP-competitive inhibition of human recombinant GST-SK 1 with an IC50 value of 0.5 µM, with no inhibition against ERK2, PI3-kinase, or PKCα at concentrations up to 60 µM.
Peptide sequence
N/A
CAS number
312636-16-1
Molecular weight
302.78
Category
Biochemicals
Other name
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Molecular formula
C₁₅H₁₁ClN₂OS
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥90% by NMR
Reconstitute instructions
DMSO (100 mM)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.