I-BET151 for cell activation
Catalog number
2220-1
Name
I-BET151 for cell activation
Size
1 mg
Price
121.00 EUR
Supplier
Details
Description
A BET bromodomain inhibitor that interacts with BRD4 and BRD3 BET proteins and displaces them from chromatin; displays highefficacy against human and murine MLL-fusion leukemic cell lines, through the induction of early cell cycle arrest and apoptosis. The mode of action is, at least in part, due to suppressing the transcription of key genes (BCL2, C-MYC and CDK6) that are critical for MLL-fusion leukemia maintenance.
Peptide sequence
N/A
CAS number
1300031-49-5
Molecular weight
415.44
Category
Biochemicals
Other name
GSK1210151A
Molecular formula
C₂₃H₂₁N₅O₃
Physical appearance
Beige to pale yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC (≥99.5% optical purity)
Reconstitute instructions
DMSO (100 mM) or Ethanol (100 mM)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
