Erastin for cell activation

Catalog number
2231-1
Name
Erastin for cell activation
Size
1 mg
Price
164.00 EUR
Supplier

Details

Description
Erastin is a selective antitumor agent that displays greater lethality in human tumour cells harbouring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating. Erastin rapidly induces an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling.
Peptide sequence
N/A
CAS number
571203-78-6
Molecular weight
547.04
Category
Biochemicals
Other name
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
Molecular formula
C₃₀H₃₁ClN₄O₄
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>50 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.