TPCA-1 for cell activation

Catalog number
2431-5
Name
TPCA-1 for cell activation
Size
5 mg
Price
175.00 EUR
Supplier

Details

Description
A potent and selective inhibitor of IκB kinase-2 (IKK-2) (IC₅₀ = 17.9 nM). Displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. TPCA-1 inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-κB nuclear localization. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.
Peptide sequence
N/A
CAS number
507475-17-4
Molecular weight
279.29
Category
Biochemicals
Other name
2-[(Aminocarbonyl)amino]-5-(4-fluor​ophenyl)-3-thiophenecarboxamide
Molecular formula
C₁₂H₁₀FN₃O₂S
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95% by HPLC
Reconstitute instructions
DMSO (~25 mg/ml) or EtOH (~3 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light and air
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.