KN-93 for cell activation

Catalog number
2524-250
Name
KN-93 for cell activation
Size
250 µg
Price
132.00 EUR
Supplier

Details

Description
Cell-permeable. KN-93 is a potent inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaM kinase II) (IC₅₀ = 0.37 μM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC₅₀ = 307 nM for Kv1.5). More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes.
Peptide sequence
N/A
CAS number
139298-40-1
Molecular weight
501.04
Category
Biochemicals
Other name
N-​[2-​[[[3-​(4-​chlorophenyl)-​2-​propen-​1-​yl]methylamino]methyl]phenyl]-​N-​(2-​hydroxyethyl)-​4-​methoxy-​benzenesulfonamide
Molecular formula
C₂₆H₂₉ClN₂O₄S
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98%
Reconstitute instructions
DMSO (>40 mg/ml)
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.