Human CellExp™ TIM-4, human recombinant

Catalog number
P1108-10
Name
Human CellExp™ TIM-4, human recombinant
Size
10 μg
Price
153.00 EUR
Supplier

Details

Target
TIMD4
Background
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.
Concentration
N/A
Synonym
TIM4; TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4, T Cell Membrane Protein 4
Other name
TIM4, TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4, T Cell Membrane Protein 4
NCBI gene number
91937
NCBI gene
TIMD4
Gene source
Human
NCBI number
Q96H15
Recombinant
Yes
Source
CHO cells
Purification
≥98%
Tested applications
SDS-PAGE, N/A
Level of endotoxin
< 0.06 EU/μg
Tested activity
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
Biological activity
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
Reesults
N/A
Binding ability
N/A
Unit
N/A
Storage condition
-20°C
Shipping under
Gel pack
Physical appearance
Lyophilized
Physical properties
Lyophilized from 0.2 μm-filtered solution in PBS
How to reconstitute
Reconstitute with 100 µl sterile water.
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants