CHIR-98014 for cell activation

Catalog number
2595-1
Name
CHIR-98014 for cell activation
Size
1 mg
Price
142.00 EUR
Supplier

Details

Description
Cell-permeable. CHIR-98014 is a potent, selective and ATP-competitive inhibitor of GSK3α and GSK3β (IC₅₀ = 0.65 and 0.58 nM, respectively). In addition, CHIR-98014 displays 500 to greater than 1000-fold selectivity towards GSK3 than other protein kinases such as cdc2 and ERK2. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.
Peptide sequence
N/A
CAS number
556813-39-9
Molecular weight
486.31
Category
Biochemicals
Other name
6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine; CT 98014
Molecular formula
C₂₀H₁₇Cl₂N₉O₂
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
>98% by HPLC
Reconstitute instructions
DMSO (~ 4 mg/ml)
Storage condition
-20 ̊C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.