IPA-3 for cell activation

Catalog number
2647-25
Name
IPA-3 for cell activation
Size
25 mg
Price
458.00 EUR
Supplier

Details

Description
IPA-3 is a cell-permeable allosteric inhibitor of PAK1 (tha p21-activated kinase 1) that is non-competitive with respect to ATP binding (IC₅₀ = 2.5 µM). It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42. Potential anti-tumor agent.
Peptide sequence
N/A
CAS number
42521-82-4
Molecular weight
350.45
Category
Biochemicals
Other name
1,​1'-​dithiobis-​2-​naphthalenol
Molecular formula
C₂₀H₁₄O₂S₂
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95%
Reconstitute instructions
DMSO (~ 25 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
48 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.