Eeyarestatin I for cell activation

Catalog number
9602-5
Name
Eeyarestatin I for cell activation
Size
5 mg
Price
186.00 EUR
Supplier

Details

Description
Eeyarestatin I is an inhibitor of the ERAD (Endoplasmic-reticulum -associated protein degradation) pathway, blocking the degradation of misfolded proteins at a dose of 8 µM. It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3 (atx3).  Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the pro-apoptotic protein NOXA.
Peptide sequence
N/A
CAS number
412960-54-4
Molecular weight
630.44
Category
Biochemicals
Other name
  3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Molecular formula
C₂₇H₂₅Cl₂N₇O₇
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>30 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.