Monoamine Oxidase B (MAO-B) Inhibitor Screening Kit (Fluorometric)

Catalog number
Monoamine Oxidase B (MAO-B) Inhibitor Screening Kit (Fluorometric)
100 assays
601.00 EUR


Kit's description
Monoamine oxidases (MAO, EC are a family of enzymes that can oxidize a wide variety of endogenous primary amines. Two isoforms, MAO-A and MAO-B, have been identified based on their substrate, inhibitor specificity, and tissue localization. MAO-B can oxidize primary amines, but its list of specific substrates (i.e. benzylamine, phenylethylamine) is more limited compared to MAO-A. MAO-B is a mitochondrial-bound enzyme that is ubiquitously expressed throughout the brain and other tissues. It has been investigated in numerous studies including Parkinson’s disease, Alzheimer’s, and tobacco addiction. Specific MAO-B inhibitors such as selegiline, & rasagiline have been used to treat Parkinson’s patients, but their benefits are considered rather modest. BioVision’s MAO-B Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of MAO-B inhibitors. The assay is based on the fluorometric detection of H2O2, one of the byproducts generated during the oxidative deamination of MAO substrate.
• Detection method: Fluorescence (Ex/Em = 535/587 nm) • Application: Screening/studying/characterizing MAO:B inhibitors
Kit's benefits
• Rapid & sensitive • High-throughput assay to screen/study/characterize potential inhibitors of monoamine oxidase B • Includes Inhibitor Control [Selegiline]
Monoamine oxidase B, MAO-B, MAO B
Kit's other name
• MAO-B Assay Buffer • OxiRedTM Probe (in DMSO) • MAO-B Enzyme (Lyophilized) • MAO-B Substrate (Lyophilized) • Developer (Lyophilized) • Inhibitor Control (Selegiline) (Lyophilized)
Storage condition
Shipping condition
gel pack
Maximum time can be stored
12 months
Species reactivity
see datasheet
Screening/studying/characterizing MAO-B inhibitors
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.