Mouse Monoclonal Anti-KIAA1967 Antibody (3G4-D11-D7)

Catalog number
A1336-100
Name
Mouse Monoclonal Anti-KIAA1967 Antibody (3G4-D11-D7)
Size
100 µg
Price
338.00 EUR
Supplier

Details

Description
Mouse Monoclonal antibody to detect KIAA1967
Raised in
Mouse
Clonality
Monoclonal Antibody (Clone#3G4-D11-D7)
Reacts with
Human, Mouse, Rat, Monkey
Immunogen
Recombinant human KIAA1967 protein fragments expressed in E.coli
Target
Cell cycle and apoptosis regulator protein 2 (Cell cycle and apoptosis regulator protein 2, Cell division cycle and apoptosis regulator protein 2, DBIRD complex subunit KIAA1967, Deleted in breast cancer gene 1 protein, DBC1, NET35, p30 DBC)
Research area
Signal Transduction
Gene number
57805
Protein number
Q8N163
Physical state
Colorless liquid
Package form
Affinity purified antibody is supplied in liquid form in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol
Purity
Affinity purified
Antibody's positive controles
Western blot: HeLa, A549, Jurkat, C6, 3T3 and COS7 cell lysates; Immunofluorescence: HeLa cells; Immunoprecipitation: HeLa cells
Approved applications with antibody dilution
Western blot; 1:1000, Immunofluorescence; 1:200, Immunoprecipitation
Scientific context
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.
Handling and storage
Before use gently mix the antibody solution. Store this antibody at -20 °C for 12 months. Refer to the label on vial
Delivery
Shipped to your lab under gel pack
Precautions
Manifactured in USA. For Research Use Only! Not to be used in humans
Released
This antibody is available to order since May 2017
Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name
Mus musculus
French translation
anticorps